Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Focusing of Light in the Eye01:16

Focusing of Light in the Eye

Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optoretinography - Mechanisms and applications.

Handbook of clinical neurology·2026
Same author

In vivo elastography of the human retina using light-evoked intrinsic actuation.

bioRxiv : the preprint server for biology·2026
Same author

Ambulatory Holter Findings in Patients with Palpitations and Structurally Normal Heart: A Prospective Study of the Prevalence and Patterns of Ventricular and Supraventricular Arrhythmias.

Journal of clinical medicine·2026
Same author

Optoretinography in R9AP-bradyopsia reveals the essential role of G-protein signaling in the human cone elongation response.

bioRxiv : the preprint server for biology·2026
Same author

Optoretinography reveals rapid rod photoreceptor movement upon rhodopsin activation.

Light, science & applications·2026
Same author

Roadmap on advances in visual and physiological optics.

Journal of optics (2010)·2025

Related Experiment Video

Updated: Jul 9, 2026

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile
05:46

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

Published on: September 20, 2024

Correcting highly aberrated eyes using large-stroke adaptive optics.

Ramkumar Sabesan1, Kamran Ahmad, Geunyoung Yoon

  • 1Institute of Optics University of Rochester, Rochester, NY 14627, USA. ramkumar@optics.rochester.edu

Journal of Refractive Surgery (Thorofare, N.J. : 1995)
|November 29, 2007
PubMed
Summary

A large-stroke deformable mirror effectively corrected significant eye aberrations, achieving near-perfect optical quality. This adaptive optics technology shows promise for assessing visual limits in eyes with irregular corneas.

More Related Videos

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
05:14

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter

Published on: September 16, 2025

Bringing the Visible Universe into Focus with Robo-AO
10:35

Bringing the Visible Universe into Focus with Robo-AO

Published on: February 12, 2013

Related Experiment Videos

Last Updated: Jul 9, 2026

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile
05:46

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

Published on: September 20, 2024

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter
05:14

Comparison of Agreement and Accuracy using Binocular Wavefront Optometer with Autorefractor and Phoropter

Published on: September 16, 2025

Bringing the Visible Universe into Focus with Robo-AO
10:35

Bringing the Visible Universe into Focus with Robo-AO

Published on: February 12, 2013

Area of Science:

  • Ophthalmology
  • Optical Engineering
  • Biomedical Optics

Background:

  • Highly aberrated eyes, such as those with keratoconus, present challenges for achieving high visual acuity.
  • Accurate correction of ocular aberrations is crucial for understanding and potentially improving visual performance limits.

Purpose of the Study:

  • To evaluate the effectiveness of a large-stroke deformable mirror in correcting substantial optical aberrations in simulated and real eyes.
  • To assess the optical performance of an adaptive optics system utilizing this mirror for highly aberrated eyes.

Main Methods:

  • An adaptive optics system incorporating a large-stroke deformable mirror (Mirao 52D) and a Shack-Hartmann wavefront sensor was employed.
  • Closed-loop correction was performed on a phase plate simulating advanced keratoconus and on the eyes of individuals with moderate keratoconus and normal vision.

Main Results:

  • The deformable mirror reduced root-mean-square (RMS) aberrations from 3.54 to 0.04 micrometers in a simulated keratoconic eye within 3-4 seconds.
  • In normal eyes, total RMS aberrations decreased from 1.73 to 0.10 micrometers; in keratoconic eyes, they reduced from 2.73 to 0.10 micrometers.

Conclusions:

  • The large-stroke deformable mirror successfully corrected significant aberrations in both normal and highly aberrated eyes, achieving excellent optical quality.
  • This technology is valuable for evaluating the maximum achievable visual performance, particularly in eyes with abnormal corneal shapes.