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Morphine influence on adenylate cyclase activity in peripheral blood lymphocytes of alcoholic patients
N B Gamaleya1, N L Vekshina, T P Nebarakova
1All-Union Scientific Research Centre for Medical and Biological Problems of Narcology, Moscow, U.S.S.R.
Alcohol and Alcoholism (Oxford, Oxfordshire)
|January 1, 1991
Abstract:
The effect of morphine on adenylate cyclase activity in lymphocytes was tested in 20 normal controls, 16 alcoholics in withdrawal and 9 sober alcoholics. Alcoholics in withdrawal were characterized by a significantly increased stimulatory effect of morphine, whereas sober alcoholics showed an inhibitory effect. The morphine effect was abolished by naloxone and correlated with the severity of withdrawal and alcohol intoxication.