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Plasma D-dimer levels in patients with typhoid fever
K Ohnishi1, F Nakamura-Uchiyama, N Komiya
1Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Sumida City, Tokyo, Japan. infection@bokutoh-hp.metro.tokyo.jp
The Southeast Asian Journal of Tropical Medicine and Public Health
|November 29, 2007
Summary
Elevated D-dimer levels in typhoid fever patients during the febrile phase suggest potential thrombus formation and fibrinolysis. Levels normalized in the convalescent phase, indicating a temporary process.
Area of Science:
- Hematology
- Infectious Diseases
- Clinical Biochemistry
Background:
- D-dimer is a marker for fibrin formation and degradation.
- Typhoid fever is a systemic infection with potential complications.
- Understanding coagulation changes in typhoid fever is clinically relevant.
Purpose of the Study:
- To investigate plasma D-dimer levels in patients with typhoid fever.
- To determine if D-dimer levels correlate with the febrile or convalescent phases of the illness.
Main Methods:
- Plasma D-dimer levels were measured in 6 patients during the febrile phase of typhoid fever.
- D-dimer levels were reassessed in 4 of these patients during the afebrile convalescent phase.
Main Results:
- All 6 patients exhibited high D-dimer levels during the febrile phase.
- D-dimer levels returned to the normal range in all 4 patients in the afebrile convalescent phase.
Conclusions:
- The findings suggest that thrombus formation and fibrinolysis occur during the febrile phase of typhoid fever.
- These coagulation alterations appear to be transient and resolve as the fever subsides.
