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Updated: Jul 9, 2026

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Published on: May 10, 2024
Association between folate-metabolizing pathway polymorphism and non-Hodgkin lymphoma
Hee Nam Kim1, Il-Kwon Lee, Yeo-Kyeoung Kim
1Genome Research Centre for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Jeollanamdo, Korea.
Genetic variations in folate metabolism enzymes impact cancer risk. Certain MTHFR, MTRR, and TYMS gene polymorphisms are linked to non-Hodgkin lymphoma (NHL) risk, influencing susceptibility to specific subtypes like DLBCL and T-cell lymphoma.
Area of Science:
- Genetics
- Oncology
- Molecular Epidemiology
Background:
- Polymorphisms in folate-metabolizing enzyme genes are implicated in various cancer risks.
- Understanding these genetic variations is crucial for identifying individuals at higher risk for hematological malignancies.
Purpose of the Study:
- To investigate the association between polymorphisms in key folate pathway genes (MTHFR, MTRR, TYMS) and the risk of non-Hodgkin lymphoma (NHL).
Main Methods:
- A population-based case-control study was conducted with 583 NHL cases and 1700 controls.
- Genotyping was performed for specific polymorphisms in the MTHFR, MTRR, and TYMS genes.
- Statistical analyses, including odds ratios (OR) and 95% confidence intervals (CI), were used to assess risk associations.
Main Results:
- MTHFR 677TT and CT genotypes showed reduced NHL risk (OR=0.61-0.79) and DLBCL risk (OR=0.56-0.68).
- MTHFR 1298CC genotype was associated with increased NHL (OR=1.71) and T-cell lymphoma risk (OR=3.05).
- MTRR 66GG and TYMS 2R2R genotypes were linked to increased DLBCL (OR=1.56) and T-cell lymphoma risk (OR=2.83), respectively. TYMS 2R3RG showed reduced DLBCL risk (OR=0.61).
Conclusions:
- MTHFR, MTRR, and TYMS gene polymorphisms appear to significantly influence the risk of developing non-Hodgkin lymphoma.
- Specific genotypes within these genes may confer differential risks for NHL subtypes, including DLBCL and T-cell lymphoma.
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