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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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Related Experiment Video

Updated: Jul 9, 2026

Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
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Hepatitis C virus and lymphoma.

D S Viswanatha1, A Dogan

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.

Journal of Clinical Pathology
|November 29, 2007
PubMed
Summary

Hepatitis C virus (HCV) is linked to non-Hodgkin lymphoma (NHL) development. Some HCV-associated NHL cases show positive responses to antiviral treatments, suggesting a therapeutic link.

Area of Science:

  • Hepatology and Oncology
  • Virology and Immunology

Background:

  • Hepatitis C virus (HCV) causes chronic liver disease, cirrhosis, and liver cancer.
  • HCV is increasingly implicated in extra-hepatic autoimmune conditions.
  • A potential link between HCV and non-Hodgkin lymphoma (NHL) is under investigation.

Purpose of the Study:

  • To explore the association between Hepatitis C virus (HCV) and the pathogenesis of non-Hodgkin lymphoma (NHL).
  • To review the histological subtypes of HCV-associated lymphomas.
  • To assess the therapeutic implications of this association.

Main Methods:

  • Review of epidemiological data.
  • Analysis of biological investigations.
  • Examination of clinical observations and patient outcomes.

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Main Results:

  • Epidemiological and clinical evidence suggests HCV involvement in a proportion of NHL cases.
  • HCV-associated lymphomas include various subtypes like marginal zone lymphoma and diffuse large B-cell lymphoma.
  • Some HCV-associated NHL cases demonstrate significant responsiveness to antiviral therapy.

Conclusions:

  • Hepatitis C virus (HCV) plays a role in the development of certain non-Hodgkin lymphomas (NHL).
  • The findings support a causative link and highlight the diversity of HCV-associated lymphomas.
  • Antiviral therapy offers a promising treatment avenue for select HCV-positive NHL patients.