Importance of perioperative blood glucose management in cardiac surgical patients
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Updated: Jul 9, 2026

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Published on: June 11, 2012
Timothy S J Shine1, Mihoko Uchikado, Claudia C Crawford
1Department of Anesthesiology, Mayo Clinic, Jacksonville, USA.
Insights
Maintaining strict blood glucose control is vital for patients undergoing cardiovascular surgery. Elevated blood glucose levels (hyperglycemia) are linked to increased complications and longer intensive care unit stays after cardiac surgery.
Area of Science:
- Anesthesiology
- Cardiovascular Surgery
- Critical Care Medicine
Background:
- Tight blood glucose control is a therapeutic goal in anesthetic management for cardiovascular surgery patients.
- Hyperglycemia is associated with increased morbidity and mortality in cardiac surgical patients.
- Complications include deep wound infection, neurologic, renal, and cardiac issues, alongside prolonged intensive care unit (ICU) stays.
Purpose of the Study:
- To review the evidence linking blood glucose levels to patient outcomes in the ICU after cardiovascular surgery.
- To discuss glucose management strategies specifically for cardiac surgery patients.
- To explore the role of insulin in intraoperative glucose regulation and its impact on patient outcomes.
Main Methods:
- Literature review of studies on blood glucose control in cardiovascular surgery.
- Analysis of data correlating hyperglycemia with postoperative complications.
- Examination of insulin
Main Results:
- Hyperglycemia is independently associated with higher rates of deep wound infection.
- Elevated glucose levels correlate with increased neurologic, renal, and cardiac complications.
- Patients with hyperglycemia experience longer intensive care unit stays.
Conclusions:
- Strict blood glucose control is crucial for improving outcomes in patients undergoing cardiovascular surgery.
- Understanding the relationship between insulin, glucose levels, and patient outcomes is essential for effective anesthetic management.
- Further research into optimal glucose management strategies, including the role of insulin, is warranted.
Abstract:
Tight blood glucose control has become a therapeutic goal for anesthetic management of patients undergoing cardiovascular surgery. We discuss the evidence for a link between blood glucose levels and rates of morbidity and mortality in cardiac surgical patients in the intensive care unit. Hyperglycemia per se has been associated with higher rates of deep wound infection, neurologic, renal, and cardiac complications following surgery, as well as longer intensive care unit stay. We review the specifics of glucose management in patients undergoing cardiac surgery and hypothermic cardiopulmonary bypass, including the role that insulin may play in regulating blood glucose levels intraoperatively and the relationship between insulin and outcome.
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