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Related Experiment Video

Updated: Jul 9, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
06:28

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization

Published on: June 4, 2020

Reference values for kaolin-activated thromboelastography in healthy children.

Kah-Lok Chan1, Robyn G Summerhayes, Vera Ignjatovic

  • 1Department of Clinical Hematology, Royal Children's Hospital, Melbourne, Australia.

Anesthesia and Analgesia
|November 29, 2007
PubMed
Summary
This summary is machine-generated.

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Establishing age-specific reference values for kaolin-activated thromboelastography (TEG) in children is crucial for accurate interpretation of coagulation status. This study provides these essential pediatric TEG values for clinical use.

Area of Science:

  • Pediatric Hematology
  • Coagulation Science
  • Point-of-Care Testing

Background:

  • Pediatric hemostasis differs significantly from adults, necessitating age-specific reference values.
  • Thromboelastography (TEG) offers valuable point-of-care assessment for coagulopathies, especially post-cardiac surgery.
  • Current interpretation challenges exist due to a lack of established pediatric TEG norms.

Purpose of the Study:

  • To establish age-specific reference values for kaolin-activated TEG in healthy children.
  • To facilitate accurate interpretation of TEG in pediatric patients.
  • To provide a basis for managing coagulopathies in children.

Main Methods:

  • Kaolin-activated TEG performed on 100 healthy children (1 month to 16 years) and 25 adults.

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  • Key TEG variables measured: reaction time, coagulation time, alpha angle, maximum amplitude, percentage lysis, and coagulation index.
  • Analysis of variance used to compare age groups.

    • Main Results:

    • Age-specific reference values for kaolin-activated TEG in children (1 month to 16 years) are presented.
    • No significant differences were observed between pediatric and adult TEG values in this study.
    • The data provides a foundational set of normal values for pediatric thromboelastography.

    Conclusions:

    • TEG results require comparison with age-specific, analyzer-specific, and activator-specific reference values for accurate interpretation.
    • The provided reference values are valuable for acute clinical settings requiring rapid hemostasis monitoring in children.
    • This research supports the clinical utility of TEG in pediatric hemostasis management.