Related Experiment Video
Updated: Jul 9, 2026
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Chronic obstructive pulmonary disease: a chronic systemic inflammatory disease.
Stephan F van Eeden1, Don D Sin
1James Hogg iCapture Centre for Cardiovascular and Pulmonary Research, University of British Columbia, and Respiratory Division, St. Paul's Hospital, Vancouver, B.C., Canada. svaneeden@mrl.ubc.ca
Respiration; International Review of Thoracic Diseases
|November 29, 2007
Summary
Chronic obstructive pulmonary disease (COPD) involves lung inflammation and systemic inflammation, increasing cardiovascular mortality risk. Understanding this systemic response is key to managing COPD complications.
Area of Science:
- Pulmonary Medicine
- Immunology
- Cardiovascular Disease
Background:
- Chronic obstructive pulmonary disease (COPD) is defined by persistent airway inflammation and lung tissue damage (emphysema).
- Inhaled irritants trigger chronic lung inflammation, directly correlating with COPD severity.
- COPD is linked to systemic inflammation, causing adverse health effects and increased cardiovascular mortality.
Purpose of the Study:
- To review the nature of the systemic inflammatory response in COPD.
- To outline clinical manifestations associated with COPD's systemic inflammation.
- To explore potential mechanisms driving these adverse health effects.
Main Methods:
- Literature review focusing on systemic inflammation in COPD.
- Analysis of clinical manifestations and health outcomes.
- Exploration of underlying pathophysiological mechanisms.
Main Results:
- COPD involves both local lung inflammation and a significant systemic inflammatory response.
- Systemic inflammation in COPD patients is associated with adverse clinical outcomes.
- Cardiovascular mortality is notably higher in individuals with COPD.
Conclusions:
- The systemic inflammatory response is a critical aspect of COPD pathophysiology.
- Understanding these systemic effects is crucial for improving patient outcomes and reducing mortality.
- Further research into the mechanisms is needed to develop targeted therapies.
Related Concept Videos
01:23Chronic Obstructive Pulmonary Disease I: Introduction
Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
01:24Chronic Obstructive Pulmonary Disease
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:19Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...