Related Experiment Video
Updated: Jul 9, 2026
Three Strategies to Induce Neurotrophic Keratitis and Nerve Regeneration in Murine Cornea
Published on: December 8, 2023
Granular corneal dystrophy manifesting after radial keratotomy
Sepehr Feizi1, Mohammad Pakravan, Ali-Reza Baradaran-Rafiee
1Labbafinejad Medical Center, Shaheed Beheshti University, Tehran, Iran. sepehrfeizi@yahoo.com
Purpose:
To report a case of granular corneal dystrophy after radial keratotomy (RK).
Methods:
A 32-year-old man presented with white radial lines in both corneas. He had a history of uncomplicated RK in both eyes 8 years ago. Preoperative refraction had been OD -3.5-0.75 x 180 and OS -3.0-0.5 x 175. The cornea was reported to be clear on postoperative examinations.
Results:
Postoperative uncorrected visual acuity was OD 20/30 and OS 20/40. Best-corrected visual acuity was 20/25 in both eyes with OD -0.5-0.5 x 60 and OS -0.75-0.5 x 80. Slit-lamp examination revealed discrete well-demarcated whitish lesions with clear intervening stroma in the central anterior cornea consistent with granular dystrophy. Similar opacities were present within the RK incisions.
Conclusions:
Production and deposition of such abnormal material could be due to keratocyte activation after RK or proliferation and migration of epithelial cells with a tendency to express abnormal keratoepithelin.
