Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Prosopagnosia01:24

Prosopagnosia

Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence and Progression of Glaucoma Following Boston Type 1 Keratoprosthesis: A Systematic Review and Meta-Analysis.

American journal of ophthalmology·2026
Same author

p16-mediated G0/G1 cell cycle arrest leads to SASP and fibrosis in Fuchs endothelial corneal dystrophy.

Cell death & disease·2026
Same author

Real-world effectiveness of topical insulin for neurotrophic keratopathy: retrospective case series of 29 eyes.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2025
Same author

Bandage contact lens wear in Boston keratoprosthesis type 1 surgery.

European journal of ophthalmology·2025
Same author

Ocular surface squamous neoplasia: insights from 67 cases at a Quebec tertiary center.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2025
Same author

Transcriptome analyses of human corneal endothelial cell lines derived from patients with Fuchs endothelial corneal dystrophy.

Scientific reports·2025

Related Experiment Video

Updated: Jul 9, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

Keratoglobus in association with posterior polymorphous dystrophy.

Mona Harissi-Dagher1, M Reza Dana, Ula V Jurkunas

  • 1Department of Ophthalmology, Cornea and External Disease Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.

Cornea
|November 29, 2007
PubMed
Summary

This case report details a 34-year-old woman with keratoglobus and posterior polymorphous corneal dystrophy (PPMD). It highlights the first documented instance of both conditions co-occurring.

More Related Videos

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Related Experiment Videos

Last Updated: Jul 9, 2026

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo
08:17

Optical Coherence Tomography: Imaging Mouse Retinal Ganglion Cells In Vivo

Published on: September 22, 2017

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Genetics

Background:

  • Keratoglobus is a rare bilateral condition characterized by generalized thinning and protrusion of the cornea.
  • Posterior polymorphous corneal dystrophy (PPMD) is a rare, inherited corneal disease affecting the endothelium.

Observation:

  • A 34-year-old woman presented with symptoms suggestive of both keratoglobus and PPMD.
  • Ophthalmologic examination included topography and specular microscopy.

Findings:

  • Corneal topography revealed steepening consistent with keratoglobus.
  • Specular microscopy showed irregular, large polymorphous changes in the corneal endothelium, indicative of PPMD.
  • Orbscan topography provided detailed descriptions of keratoglobus findings.

Implications:

  • This is the first reported case of co-existing keratoglobus and PPMD.
  • The findings contribute to understanding the clinical presentation and diagnostic features of these rare corneal conditions.
  • Highlights the utility of advanced imaging techniques in diagnosing complex corneal pathologies.