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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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A variant of Poland syndrome associated with dextroposition

Hakan Mutlu1, Onur Sildiroglu, Cinar C Basekim

  • 1Gulhane Military Medical Academy, Haydarpasa Teaching Hospital, Department of Radiology, Istanbul, Turkey. hakanmutlu1@yahoo.com

Journal of Thoracic Imaging
|November 29, 2007
PubMed

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In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
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