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Updated: Jul 9, 2026

In vivo Application of the REMOTE-control System for the Manipulation of Endogenous Gene Expression
Published on: March 29, 2019
Beyond the gene.
Evelyn Fox Keller1, David Harel
1Program in Science, Technology, and Society, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
Biologists struggle to define the gene. This paper proposes a new concept, the "genitor," to better capture inheritance, distinguishing static traits from dynamic functions and aligning with modern biology.
Area of Science:
- Genetics and Molecular Biology
- Evolutionary Biology
Background:
- The classical definition of a gene faces challenges in contemporary biology.
- Disagreement persists among biologists regarding a unified gene concept.
- Emerging complex links between biological structure and functionality complicate existing paradigms.
Purpose of the Study:
- To address the definitional crisis surrounding the gene.
- To propose a novel conceptual framework for inheritance.
- To offer a richer, more expressive, and clearer alternative to the gene concept.
Main Methods:
- Review of existing challenges in gene definition.
- Conceptual development of an alternative framework.
- Comparison of the proposed framework with the classical genotype/phenotype model.
Main Results:
- Introduction of the
- genitor
- (genetic functor) as a proposed alternative.
- The
- genitor
- concept separates static inheritance from dynamic functionality.
- The proposed framework integrates complex structure-function relationships found in modern biology.
Conclusions:
- The
- genitor
- offers a more robust model for understanding inheritance.
- This new concept aligns with and clarifies recent biological discoveries.
- The
- genitor
- provides a clearer distinction between an organism's inherited state and its functional output.
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