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Corpus callosum abnormalities in women with borderline personality disorder and comorbid attention-deficit
Nicolas Rüsch1, Eileen Luders, Klaus Lieb
1Rüsch, Zahn, Ebert, Tebartz van Elst-Department of Psychiatry and Psychotherapy, University of Freiburg, and the South German Brain Imaging Center, Freiburg, Germany. nicolas.ruesch@uniklinik-freiburg.de
Objective:
Decreased brain volumes in prefrontal, limbic and parietal areas have been found in women with borderline personality disorder (BPD). Recent models suggest impaired structural and functional connectivity in this condition. To investigate this, we studied the thickness of the corpus callosum, the largest connecting fibre bundle in the human brain.
Methods:
We acquired magnetic resonance imaging scans from 20 healthy women and 20 women with BPD and comorbid attention-deficit hyperactivity disorder. A novel computational mesh-based method was applied to measure callosal thickness at high spatial resolution.
Results:
Women with BPD had a thinner isthmus of the corpus callosum, compared with healthy women. In the patient group, a history of childhood sexual abuse was associated with a thinner posterior body of the corpus callosum.
Conclusion:
Interhemispheric structural connectivity involving parietal and temporal areas may be impaired in women with BPD and comorbid attention-deficit hyperactivity disorder.
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