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Updated: Jul 9, 2026
05:16
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Non-surgical interventions for threatened and recurrent miscarriages.
1Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore 117597.
Singapore Medical Journal
|November 29, 2007
Summary
Evidence-based management of recurrent miscarriage requires identifying causes. Only combined aspirin and heparin for antiphospholipid syndrome and clindamycin for bacterial vaginosis are proven effective in randomized controlled trials.
Area of Science:
- Reproductive Medicine
- Obstetrics and Gynecology
- Clinical Management
Background:
- Threatened and recurrent miscarriages necessitate diverse management strategies.
- Effective treatment relies on identifying underlying etiological factors.
- Evidence-based approaches are crucial for improving pregnancy outcomes.
Purpose of the Study:
- To review current interventions for threatened and recurrent miscarriages.
- To highlight evidence-based treatments supported by randomized controlled trials (RCTs).
- To discuss the efficacy and controversy surrounding various management options.
Main Methods:
- Literature review of surgical and non-surgical interventions.
- Analysis of evidence from randomized controlled trials (RCTs).
- Evaluation of treatments for specific etiological factors and empirical approaches.
Main Results:
- Combined aspirin and heparin for antiphospholipid syndrome are proven effective.
- Screening and treatment of bacterial vaginosis with clindamycin reduce miscarriage rates.
- Metformin for polycystic ovarian (PCO) syndrome shows promise, requiring further RCT data.
Conclusions:
- Directed treatment based on identified causes can reduce miscarriage rates.
- Heparin for inherited thrombophilias and other treatments remain controversial.
- Supportive care and dydrogesterone may benefit threatened miscarriages; bed rest has no proven benefit.
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