Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperinflation and its management in COPD.

Luis Puente-Maestu1, William W Stringer

  • 1Hospital General Universitario Gregorio Marañón, Servicio de Neumologia, Madrid, Spain. lpuente.hgugm@madrid.salud.org

International Journal of Chronic Obstructive Pulmonary Disease
|November 30, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-O<sub>2</sub>ligation of hemoglobin links aerobic and anaerobic metabolism.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

COVID-19 Has Taught Us That Not All COPD Exacerbations are Created Equal.

Annals of the American Thoracic Society·2026
Same author

Addressing Methodological Gaps: A Systematic Review and Meta-Analysis of Beetroot Juice and Exercise Capacity in Chronic Obstructive Pulmonary Disease.

Nutrition reviews·2026
Same author

Hyperlactatemia and pulmonary gas exchange at rest and during exercise: lessons from patients on metformin.

European journal of applied physiology·2026
Same author

American College of Chest Physicians algorithm for lung resective surgery: Real-life validation.

Pulmonology·2026
Same author

Serum extracellular vesicle RNA profiles in long COVID: insights from exercise-induced gene modulation.

Scientific reports·2026
Same journal

SPG7-Mediated Regulation of mPTP and Mitochondrial Flickering in COPD: A Bioinformatics-Based Prediction of Mechanistic Framework.

International journal of chronic obstructive pulmonary disease·2026
Same journal

Prognostic Value of Chest CT-Derived Pectoralis Muscle Metrics for In-Hospital Mortality and Invasive Mechanical Ventilation in AECOPD.

International journal of chronic obstructive pulmonary disease·2026
Same journal

Clinical Disease Burden in Patients with Chronic Obstructive Pulmonary Disease and Type 2 Inflammation in Japan: A Retrospective Database Analysis (EUROS Study).

International journal of chronic obstructive pulmonary disease·2026
Same journal

Comparative Effectiveness and Safety of Fluticasone-Umeclidinium-Vilanterol and Beclomethasone-Glycopyrronium-Formoterol Single-Inhaler Triple Therapies for COPD: Real-World Observational Study [Letter].

International journal of chronic obstructive pulmonary disease·2026
Same journal

Real-Life Effectiveness of Aclidinium/Formoterol on COPD Control: The REDACT Observational Study.

International journal of chronic obstructive pulmonary disease·2026
Same journal

Effective-Component Compatibility of Bufei Yishen Formula Alleviates Alveolar Epithelial Barrier Damage in COPD Through Inhibition of p38 MAPK Phosphorylation.

International journal of chronic obstructive pulmonary disease·2026
See all related articles

Chronic obstructive pulmonary disease (COPD) involves airflow limitation and lung damage. Measuring this limitation and dynamic hyperinflation helps understand symptoms like dyspnea and exercise intolerance.

Area of Science:

  • Pulmonary Medicine
  • Respiratory Physiology

Background:

  • Chronic obstructive pulmonary disease (COPD) is defined by irreversible airflow limitation.
  • Key pathological features include airway inflammation and emphysema, leading to expiratory airflow limitation and dynamic hyperinflation.
  • These lead to increased respiratory system load, reduced respiratory muscle performance, dyspnea, exercise intolerance, and ventilatory failure.

Purpose of the Study:

  • To explore the pathophysiology of airflow limitation and dynamic hyperinflation in COPD.
  • To discuss methods for assessing airflow limitation and dynamic hyperinflation.
  • To review current and potential therapeutic interventions.

Main Methods:

  • Spirometry indexes like vital capacity and inspiratory capacity are used.

Related Experiment Videos

  • Advanced methods include superimposing tidal breath flow-volume loops and negative expiratory pressure (NEP) technique.
  • NEP is considered more accurate and applicable during spontaneous breathing.

    • Main Results:

    • Airflow limitation and dynamic hyperinflation are key functional consequences of COPD pathology.
    • Serial inspiratory capacity measurements during exercise can track dynamic hyperinflation trends.
    • These trends correlate with dyspnea, respiratory pattern, exercise tolerance, and gas exchange.

    Conclusions:

    • Understanding and measuring airflow limitation and dynamic hyperinflation are crucial in COPD management.
    • Various therapeutic strategies exist to palliate or ameliorate airflow limitation.
    • Further research is needed for a definitive definition and consistent measurement of dynamic hyperinflation.