Related Experiment Video
Updated: Jul 9, 2026

Establishment and Evaluation of a Risk Prediction Model for Pathological Escalation of Gastric Low-Grade Intraepithelial Neoplasia
Published on: February 16, 2024
[Lead point as a poor prognostic factor in the therapy of invagination in children]
I M Djordjević1, R Milićević, N Djordjević
1Klinika za deciju hirurgiju KC Nis.
Insights
Invagination in children is often idiopathic, but a specific "leading point" significantly impacts clinical presentation and prognosis. Identifying this leading point is crucial for effective treatment and improved outcomes in pediatric bowel obstruction.
Area of Science:
- Pediatric Surgery
- Gastroenterology
Context:
- Intussusception is a common cause of bowel obstruction in infants and young children, typically occurring between 3 and 12 months of age.
- Idiopathic intussusception accounts for 90-95% of cases, while 5-10% have a specific identifiable cause (leading point).
Purpose:
- To evaluate the prognostic value of biochemical tests (hemograms, glucose, electrolytes) in intussusception.
- To determine the influence of a leading point on the management and outcomes of intussusception.
Summary:
- This retrospective study analyzed 65 patients with intussusception, divided into idiopathic and leading point groups.
- Results indicated that the presence of a leading point significantly affects clinical presentation, laboratory findings, diagnostic and therapeutic approaches, and overall prognosis.
Impact:
- Findings highlight the importance of identifying leading points in intussusception for tailored therapeutic strategies.
- Understanding the prognostic implications of leading points can guide clinical decision-making and improve patient outcomes in pediatric bowel obstruction.
Unlabelled:
Invagination is specific form of bowel opstruction that is seen in 1-4 children per 1000 births, usually in the period from 3 to 12 months of age. In 90-95 % reason for invagination in unknown so we called this forms idiopathic. In 5-10% invagination is caused by specific leading point. THE AIM of this retrospective study was to determinate prognostic valye of used biochemical tests (hemograms, glucosa, electrolites ( levels of Na+, K+, Ca+ and Cl-) and to prove bad influence of existing "leading point" in therapy of invagination (weather it will be surgical or hydrostatic desinvagination).
Methods:
We analised 65 patients with invagination. We devided all our patients into 2 groups: first group consisted patients with idiopathic forms of invagination, and the other one were patients with invagination coused by specific leading point. RESULTS proved that leading point in invagination has great implications on clinical presentation, laboratory results, diagnostic and therapeutic procedure, and finaly in prognosis.