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Updated: Jul 9, 2026

Generation and Quantitative Characterization of Functional and Polarized Biliary Epithelial Cysts
Published on: May 16, 2020
[Pathophysiology of cholangiocytes: recent advances]
Maria Grazia Mancino1, Domenico Alvaro
1Divisione di Gastroenterologia, Dipartimento di Medicina Clinica, Università La Sapienza, Roma.
Abstract:
A bulk of researches performed in the last decade highlighted the extraordinary biological properties of cholangiocytes involved in a number of important processes such as bile formation, proliferation, injury repair, fibrosis, angiogenesis and regulation of blood flow. Cholangiocytes proliferation is a key mechanism capable of conditioning the evolution of liver damage. Proliferating cholangiocytes, in fact, acquire the phenotype of neuroendocrine cells and secrete different substances which represent the tools of cross-talk with other hepatic cells. Recent advances on the molecular and cell biology of cholangiocytes are opening new potential therapeutic perspectives for the human chronic liver diseases.
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