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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
[Gastrointestinal tuberculosis--case report]
Darko Kosćak1, Josip Lovrić, Damir Koprek
1Djelatnost za kirurgiju, Opća bolnica Bjelovar, Bjelovar, Hrvatska. darko.koscak@bj.t-com.hr
Abstract:
Isolated tuberculosis of gastrointestinal tract is a very rare disease most commonly localized in the ileo-cecal region (over 85% of the cases). The main object of surgical therapy is intraperitoneal tuberculosis (IP-TB), which leads to complications such as bowel obstruction, perforation, fistulation and bleeding. Since gastrointestinal tuberculosis can mimic symptoms found in Crohns' disease and ileocecal cancer, definitive diagnosis can only be obtained by the finding of Mycobacterium tuberculosis in tissue and stool sample as well as by positive microbacterial cultivation. A 35 year old female patient was admitted to surgical ward with clinical and radiological signs of ileus. From personal medical history as well as previous medical documentation we learned that the patient had been treated in 1995 for lung and larynx tuberculosis at Jordanovac Hospital in Zagreb. After preoperative preparation, the patient underwent surgery during which we found numerous stenoses in the region of terminal ileum and cecum. Due to the patient's general condition, surgical treatment was performed in two acts. In the first we established an L-L ileotransverse anastomosis, and in the second we made the resection. The diagnosis was confirmed by histological findings of Mycobaterium tuberculosis in stool and tissue samples as well as in resection material during operation. The early postoperative period proceeded free from complications and after surgical treatment the patient was referred to the Klenovnik Special Hospital for Pulmonary Diseases. On follow up 18 months after the surgery, there were no signs of gastrointestinal involvement.
Insights
This case study highlights a rare instance of isolated gastrointestinal tuberculosis (GI-TB) in the ileocecal region. Surgical intervention and confirmed diagnosis of Mycobacterium tuberculosis led to successful patient recovery without recurrence.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Surgical Oncology
Background:
- Isolated gastrointestinal tuberculosis (GI-TB) is rare, typically affecting the ileocecal region.
- GI-TB can present with symptoms mimicking Crohn's disease or ileocecal cancer, complicating diagnosis.
- Intraperitoneal tuberculosis (IP-TB) often requires surgical management due to potential complications like obstruction and perforation.
Observation:
- A 35-year-old female with a history of pulmonary and laryngeal tuberculosis presented with ileus.
- Surgical exploration revealed significant stenoses in the terminal ileum and cecum.
- Diagnosis was confirmed by identifying Mycobacterium tuberculosis in tissue and stool samples.
Findings:
- Surgical treatment involved a two-stage approach: L-L ileotransverse anastomosis followed by resection.
- Histological examination confirmed Mycobacterium tuberculosis in resected tissue and stool.
- The patient experienced an uncomplicated postoperative recovery.
Implications:
- This case underscores the importance of considering GI-TB in patients with a history of tuberculosis presenting with abdominal symptoms.
- Accurate diagnosis relies on microbiological confirmation.
- Surgical management can be effective for complicated GI-TB, with potential for long-term recovery.
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