Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 9, 2026

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry
08:56

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Published on: November 22, 2024

Phytotoxic Eremophilanes from Ligularia macrophylla.

Charles L Cantrell1, Stephen O Duke, Frank R Fronczek

  • 1USDA-ARS, Natural Products Utilization Research Unit, University, MS 38677, USA. clcantr1@olemiss.edu

Journal of Agricultural and Food Chemistry
|November 30, 2007
PubMed
Summary

Phytotoxic eremophilanes and antifungal fatty acids were isolated from Ligularia macrophylla roots. One eremophilane showed significant herbicidal and insecticidal activity, with its crystal structure determined.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Capsinoids (non-pungent TRPV1 agonists) promote mild hypothermia and improved outcome following stroke in aged mice.

bioRxiv : the preprint server for biology·2026
Same author

Establishment of a versatile virus-based system for elucidating herbicide resistance in Galium aparine.

Plant physiology·2026
Same author

Analysis of glutamine synthetase target-site mutations and their role in endowing glufosinate-ammonium resistance.

Pest management science·2026
Same author

Phytotoxic activity of grammicin produced by the fungus Xylaria grammica (Ascomycota) recovered from infected lesions on Handroanthus serratifolius (Bignoniaceae) leaves.

Pest management science·2026
Same author

High Temperatures Are Required for Expression of Metabolic Resistance to Cyhalofop-Butyl in a Biotype of <i>Echinochloa crus-galli</i>.

Journal of agricultural and food chemistry·2026
Same author

Peritoneal delivery of capsinoids, nonpungent TRPV1 agonists, induces mild hypothermia in conscious mice through TRPV1 activation of visceral vagal afferents.

Scientific reports·2025

Area of Science:

  • Natural Product Chemistry
  • Plant Biochemistry
  • Chemical Ecology

Background:

  • Ligularia macrophylla is a plant species known for its potential medicinal properties.
  • Phytotoxic and antifungal compounds are crucial for plant defense and have agricultural applications.
  • Eremophilanes and fatty acids are classes of natural products with diverse biological activities.

Purpose of the Study:

  • To isolate and identify phytotoxic and antifungal compounds from Ligularia macrophylla roots.
  • To evaluate the biological activity of isolated compounds against various organisms.
  • To determine the X-ray crystal structure of a key eremophilane compound.

Main Methods:

  • Systematic bioassay-guided fractionation of plant extracts.
  • Isolation and purification of chemical compounds using chromatographic techniques.

Related Experiment Videos

Last Updated: Jul 9, 2026

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry
08:56

Detection of Regulated Ergot Alkaloids in Food Matrices by Liquid Chromatography-Trapped Ion Mobility Spectrometry-Time-of-Flight Mass Spectrometry

Published on: November 22, 2024

  • Structure elucidation using spectroscopic methods and X-ray crystallography.
  • Bioassays for phytotoxicity, antifungal activity, and insecticidal effects.

    • Main Results:

    • Four phytotoxic eremophilanes and two antifungal fatty acids were isolated.
    • Eremophilanes significantly inhibited monocot (bentgrass) growth but not dicot (lettuce) growth.
    • 6beta-angeloyloxy-10beta-hydroxyfuranoeremophilane exhibited potent herbicidal activity (IC50 = 2.94 microM) and reduced termite feeding.
    • The X-ray crystal structure of 6beta-angeloyloxy-10beta-hydroxyfuranoeremophilane was determined.

    Conclusions:

    • Ligularia macrophylla roots contain potent phytotoxic eremophilanes and antifungal fatty acids.
    • 6beta-angeloyloxy-10beta-hydroxyfuranoeremophilane is a promising candidate for natural herbicide and insecticide development.
    • Further research is needed to elucidate the mode of action of the most active eremophilane.