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Updated: Jul 9, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations
09:34

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Stem cells and combinatorial science

Yue Qin Fang1, Wan Qing Wong, Yan Wen Yap

  • 1Division of Chemistry and Biological Chemistry, Nanyang Technological University, 1 Nanyang Walk, Block 5, Level 3, Singapore.

Combinatorial Chemistry & High Throughput Screening
|November 30, 2007
PubMed

Insights

High throughput screening advances stem cell research for degenerative diseases. This review explores combinatorial techniques and signaling pathways to control stem cell self-renewal and differentiation.

Area of Science:

  • Biotechnology
  • Stem Cell Biology
  • Drug Discovery

Background:

  • Stem cell therapies offer potential cures for degenerative diseases.
  • Controlling stem cell self-renewal and differentiation is crucial for therapeutic applications.

Purpose of the Study:

  • To review historic and recent progress in stem cell research.
  • To highlight the role of combinatorial and high throughput screening (HTS) in stem cell manipulation.
  • To serve as a resource for the combinatorial science community.

Main Methods:

  • Review of literature on stem cell biology (pluripotent and multipotent cells).
  • Analysis of cellular signal transduction pathways relevant to stem cells.
  • Examination of HTS techniques, including small-molecule ligand libraries and surface-immobilized molecule arrays.

Main Results:

  • Progress in stem cell technologies and their therapeutic potential.
  • Identification of key signaling pathways influencing stem cell fate.
  • Demonstration of HTS applicability in stem cell research.

Conclusions:

  • Combinatorial and HTS methods are powerful tools for stem cell research.
  • Future trends suggest continued integration of HTS for stem cell manipulation.
  • This review consolidates knowledge for advancing stem cell-based therapies.

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