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Related Experiment Video

Updated: Jul 9, 2026

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

Published on: October 25, 2018

Stem cells and combinatorial science.

Yue Qin Fang¹, Wan Qing Wong, Yan Wen Yap

¹Division of Chemistry and Biological Chemistry, Nanyang Technological University, 1 Nanyang Walk, Block 5, Level 3, Singapore.

Combinatorial Chemistry & High Throughput Screening

|November 30, 2007

Summary

This summary is machine-generated.

High throughput screening advances stem cell research for degenerative diseases. This review explores combinatorial techniques and signaling pathways to control stem cell self-renewal and differentiation.

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A Combinatorial Single-cell Approach to Characterize the Molecular and Immunophenotypic Heterogeneity of Human Stem and Progenitor Populations

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Area of Science:

Biotechnology
Stem Cell Biology
Drug Discovery

Background:

Stem cell therapies offer potential cures for degenerative diseases.
Controlling stem cell self-renewal and differentiation is crucial for therapeutic applications.

Purpose of the Study:

To review historic and recent progress in stem cell research.
To highlight the role of combinatorial and high throughput screening (HTS) in stem cell manipulation.
To serve as a resource for the combinatorial science community.

Main Methods:

Review of literature on stem cell biology (pluripotent and multipotent cells).
Analysis of cellular signal transduction pathways relevant to stem cells.
Examination of HTS techniques, including small-molecule ligand libraries and surface-immobilized molecule arrays.

Main Results:

Progress in stem cell technologies and their therapeutic potential.
Identification of key signaling pathways influencing stem cell fate.
Demonstration of HTS applicability in stem cell research.

Conclusions:

Combinatorial and HTS methods are powerful tools for stem cell research.
Future trends suggest continued integration of HTS for stem cell manipulation.
This review consolidates knowledge for advancing stem cell-based therapies.