Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Applications of protein microarray technology.

Sheng-Ce Tao1, Chien-Sheng Chen, Heng Zhu

  • 1Department of Pharmacology and Molecular Sciences/High Throughput Biology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Combinatorial Chemistry & High Throughput Screening
|November 30, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pro-inflammatory microbiota mediates the effect of host risk genes in Crohn's disease.

Frontiers in microbiology·2026
Same author

Virion display reveals MD-1 as an endogenous agonist for the orphan receptor GPRC5B.

Science signaling·2026
Same author

Computed Tomography-Based Morphometric Analysis Reveals Intercondylar Notch Stenosis and Osteophytes Are Associated With Anterior Cruciate Ligament Injury.

Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association·2026
Same author

[Research on 5-Fluorouracil-Induced Injury in Human Intestinal Organoids].

Zhongguo shi yan xue ye xue za zhi·2026
Same author

[Biological Characteristics of Human Umbilical Cord Mesenchymal Stem Cells Transduced with a <i>BMP4</i>-Carrying Adenovirus].

Zhongguo shi yan xue ye xue za zhi·2026
Same author

[The Application of Human Lung Organoids for Assessing the Cyclophosphamide-Induced Pulmonary Toxicity and Potential Mechanisms].

Zhongguo shi yan xue ye xue za zhi·2026
Same journal

Integrated Multi-Omics Identification of Novel Diagnostic Biomarkers and Immunometabolic Therapeutic Targets in Osteoporosis via Machine Learning.

Combinatorial chemistry & high throughput screening·2026
Same journal

Exploration and Prospects of Core Research Hotspots in the Mechanisms of Traditional Chinese Medicine for Treating Digestive System Malignancies Based on Bibliometrics.

Combinatorial chemistry & high throughput screening·2026
Same journal

Investigating the Potential Pharmacological Mechanisms of Huangqi in Allergic Rhinitis Using Network Pharmacology and Molecular Docking Strategies.

Combinatorial chemistry & high throughput screening·2026
Same journal

DNMT3A-driven Clonal Expansion of Hematopoiesis Influences Autoimmunity Mediated by Distinct Immune Cell Populations: A Mendelian Randomization Study.

Combinatorial chemistry & high throughput screening·2026
Same journal

UPLC-Q-TOF-MS/MS Combined with Network Pharmacology and Molecular Docking Revealed the Mechanism of Zhi Ke He Ji Oral Solution for the Treatment of Pneumonia.

Combinatorial chemistry & high throughput screening·2026
Same journal

Analysis of Chemical Components and Pharmacological Activities of Different Processing Methods in Magnolia denudata Desr. 'Hailuo' Using GC-MS and Network Pharmacology.

Combinatorial chemistry & high throughput screening·2026
See all related articles

Protein microarrays are versatile proteomic tools for high-throughput research. Advances in fabrication and detection enhance their sensitivity and specificity for scientific and diagnostic applications.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Proteomics

Background:

  • Protein microarrays are advanced proteomic technologies crucial for large-scale, high-throughput studies.
  • Significant advancements have occurred in protein microarray fabrication and application.

Purpose of the Study:

  • To review the progress and applications of protein microarrays.
  • To highlight the capabilities of analytical and functional protein microarrays.

Main Methods:

  • Large-scale cloning of expression-ready ORFs (Open Reading Frames).
  • High-throughput protein purification techniques.
  • Development of novel surface chemistries and protein delivery systems.
  • Improved detection methods for enhanced sensitivity and specificity.

Related Experiment Videos

Main Results:

  • Analytical protein microarrays serve as powerful multiplexed detection platforms using immobilized probes like antibodies.
  • Functional protein microarrays are increasingly used for drug discovery, protein interaction studies, and immune response analysis.
  • Both types show improved sensitivity and specificity, with emerging technologies continuously enhancing capabilities.

Conclusions:

  • Protein microarrays are essential tools in scientific research and clinical diagnostics.
  • Ongoing technological advancements promise broader applications and improved performance.
  • These platforms offer significant potential for biological discovery and disease diagnosis.