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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

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Effects of diabetes on murine lipoproteins and vascular disease

Hayes M Dansky1, Ira J Goldberg

  • 1Department of Experimental Medicine, Merck Research Labs, Rahway, NJ 07065, USA. hayes_dansky@merck.com

Current Drug Targets
|November 30, 2007
PubMed

Insights

Developing accurate mouse models for diabetic cardiovascular disease is challenging. While hyperlipidemia drives atherosclerosis in mice, the roles of hyperglycemia and insulin resistance remain unclear.

Area of Science:

  • Cardiovascular Science
  • Metabolic Disease Research
  • Animal Models in Medicine

Background:

  • Human diabetic cardiovascular disease lacks a clear mouse model.
  • Understanding the drivers of vascular disease in type 2 diabetes is limited.
  • Hyperglycemia's role in human vascular disease is not fully elucidated.

Purpose of the Study:

  • To review mouse models that mimic aspects of diabetic cardiovascular disease.
  • To assess the utility of mouse models for studying hyperglycemia and atherosclerosis.
  • To clarify the contributions of hyperlipidemia, hyperglycemia, and insulin resistance to diabetic vascular disease.

Main Methods:

  • Review of existing literature on mouse models of type 1 and type 2 diabetes.
  • Analysis of models recapitulating diabetic dyslipidemia, hyperglycemia/insulin resistance, and vascular disease.
  • Evaluation of studies investigating the relationship between diabetes and atherosclerosis in mice.

Main Results:

  • Mouse models can replicate diabetic dyslipidemia and hyperglycemia/insulin resistance.
  • Hyperlipidemia is a significant driver of atherosclerotic vascular disease in mice.
  • The impact of hyperglycemia and insulin resistance on murine atherosclerosis is uncertain.

Conclusions:

  • Mouse models are valuable tools for studying diabetic cardiovascular disease.
  • Hyperlipidemia is a key factor in atherosclerosis development in diabetic mice.
  • Further research is needed to clarify the effects of hyperglycemia and insulin resistance on diabetic vascular disease in mice.

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