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Updated: Jul 9, 2026

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
08:20

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol

Published on: December 30, 2016

Molecular targets of FoxP3+ regulatory T cells

Chang H Kim1

  • 1Department of Comparative Pathobiology, 725 Harrison Street, Purdue University, West Lafayette, IN 47907, USA. chkim@purdue.edu

Mini Reviews in Medicinal Chemistry
|November 30, 2007
PubMed

Insights

FoxP3+ T cells are crucial in immune and cancer diseases. This review explores molecular targets to precisely control these cells for disease prevention and treatment.

Area of Science:

  • Immunology
  • Oncology
  • Cellular Biology

Background:

  • FoxP3+ T cells play significant roles in immunological and cancerous diseases.
  • Current research focuses on precise control of FoxP3+ T cell functions.

Purpose of the Study:

  • To review potential molecular targets for regulating FoxP3+ T cells.
  • To advance strategies for disease prevention and cure by manipulating these cells.

Main Methods:

  • Literature review of immunological and cancer research.
  • Analysis of molecular pathways regulating FoxP3+ T cell biology.

Main Results:

  • Established roles of FoxP3+ T cells in various diseases.
  • Identified key molecular targets for fine-tuning FoxP3+ T cell generation, migration, expansion, and function.

Conclusions:

  • Precise regulation of FoxP3+ T cells offers therapeutic potential.
  • Targeting these molecular pathways could lead to novel treatments for immune and cancerous diseases.

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