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Updated: Jul 9, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
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Synthetic corneal inlays.

Deborah F Sweeney1, Antti Vannas, Timothy C Hughes

  • 1Vision Cooperative Research Centre, Sydney, Australia. d.sweeney@ier.org.au

Clinical & Experimental Optometry
|November 30, 2007
PubMed
Summary

Synthetic perfluoropolyether (PFPE) corneal inlays demonstrate excellent long-term biocompatibility and biostability in rabbit models. These findings support PFPE as a safe alternative for refractive surgery, with ongoing clinical trials.

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Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Corneal Research

Background:

  • The Vision Cooperative Research Centre developed a synthetic polymer for corneal implants.
  • Previous research focused on eye research and technology, leading to this innovation.

Purpose of the Study:

  • To present the development of a synthetic perfluoropolyether (PFPE) corneal inlay.
  • To evaluate the physical and biological requirements for PFPE corneal inlays.
  • To assess the long-term biocompatibility and biostability of PFPE corneal inlays.

Main Methods:

  • Development of a synthetic perfluoropolyether (PFPE) polymer.
  • Surgical implantation of PFPE inlays into corneal flaps in a rabbit model.
  • Monitoring of implants over a two-year period, with extended observation up to three years post-implantation.

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Published on: September 12, 2014

Related Experiment Videos

Last Updated: Jul 9, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
06:46

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies

Published on: February 15, 2019

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

Main Results:

  • PFPE implants exhibited excellent biocompatibility and biostability in the rabbit model.
  • No adverse reactions or degradation of the corneal tissue were observed.
  • Phase 1 clinical trials are currently underway based on these promising results.

Conclusions:

  • Corneal inlays made from PFPE are biocompatible with corneal tissue in the long term.
  • PFPE inlays offer a safe and biologically acceptable alternative to existing refractive surgery methods.
  • Continued research and clinical trials are warranted to further validate PFPE corneal inlays.