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Updated: Jul 9, 2026

CorrelationCalculator and Filigree: Tools for Data-Driven Network Analysis of Metabolomics Data
Published on: November 10, 2023
Integrative analysis for finding genes and networks involved in diabetes and other complex diseases
Regine Bergholdt1, Zenia M Størling, Kasper Lage
1Steno Diabetes Center, Niels Steensensvej 2, DK-2820 Gentofte, Denmark. rber@steno.dk
Abstract:
We have developed an integrative analysis method combining genetic interactions, identified using type 1 diabetes genome scan data, and a high-confidence human protein interaction network. Resulting networks were ranked by the significance of the enrichment of proteins from interacting regions. We identified a number of new protein network modules and novel candidate genes/proteins for type 1 diabetes. We propose this type of integrative analysis as a general method for the elucidation of genes and networks involved in diabetes and other complex diseases.
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