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Updated: Jul 9, 2026
Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
Macrophage-derived simian immunodeficiency virus exhibits enhanced infectivity by comparison with T-cell-derived
Peter J Gaskill1, Michelle Zandonatti, Tim Gilmartin
1The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-2030, La Jolla, CA 92037, USA.
Abstract:
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infect and productively replicate in macrophages and T lymphocytes. Here, we show that SIV virions derived from macrophages have higher levels of infectivity than those derived from T cells. The lower infectivity of T-cell-derived viruses is influenced by the quantity or type of mannose residues on the virion. Our results demonstrate that the cellular origin of a virus is a major factor in viral infectivity. Cell-type-specific factors in viral infectivity, and organ-specific or disease stage-specific differences in cellular derivation of virions, can be critical in the pathogenesis of HIV and AIDS.
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