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Updated: Jul 9, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood

Published on: October 12, 2012

Heparin-induced thrombocytopenia.

David W Unkle¹

¹Acute/Critical Care Nurse Practitioner Program, School of Nursing, University of Medicine & Dentistry of New Jersey, Stratford, NJ, USA.

Orthopedic Nursing

|November 30, 2007

Summary

Venous thromboembolism affects 25% of hospitalized patients annually. This article details heparin-induced thrombocytopenia, a serious adverse drug reaction to heparin therapy, covering its causes, diagnosis, and management.

Area of Science:

Internal Medicine
Pharmacology
Hematology

Background:

Venous thromboembolism (VTE), encompassing deep vein thrombosis and pulmonary embolism, affects 25% of hospitalized patients and causes 10% of inpatient deaths.
Heparin is a widely prescribed anticoagulant, administered to over 12 million patients annually in the US for VTE treatment and prevention.
Heparin-induced thrombocytopenia (HIT) is a critical antibody-mediated adverse drug reaction to heparin therapy with severe complications.

Purpose of the Study:

To discuss the pathogenesis, diagnosis, and treatment of heparin-induced thrombocytopenia (HIT).

Main Methods:

This article reviews existing literature on heparin-induced thrombocytopenia.
It synthesizes information on the underlying mechanisms, diagnostic criteria, and therapeutic strategies for HIT.

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Published on: October 12, 2012

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Main Results:

Heparin-induced thrombocytopenia is a significant complication of heparin therapy.
Early recognition and appropriate management are crucial for patient outcomes.

Conclusions:

Understanding the pathogenesis, diagnosis, and treatment of HIT is essential for clinicians managing patients on heparin.
Prompt diagnosis and alternative anticoagulation strategies can mitigate the life-threatening risks associated with HIT.