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Updated: Jul 9, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Biological targets for therapeutic interventions in COPD: clinical potential
Girolamo Pelaia1, Alessandro Vatrella, Luca Gallelli
1Department of Experimental and Clinical Medicine, University "Magna Graecia" of Catanzaro, Italy. pelaia@unicz.it
Abstract:
COPD is a widespread inflammatory respiratory disorder characterized by a progressive, poorly reversible airflow limitation. Currently available therapies are mostly based on those used to treat asthma. However, such compounds are not able to effectively reduce the gradual functional deterioration, as well as the ongoing airway and lung inflammation occurring in COPD patients. Therefore, there is an urgent need to improve the efficacy of the existing drug classes and to develop new treatments, targeting the main cellular and molecular mechanisms underlying disease pathogenesis. These therapeutic strategies will be highlighted in the present review.
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