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Updated: Jul 9, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Are hypertensive elderly patients treated differently?

Amy D G Huebschmann¹, Caroline Bublitz, Robert J Anderson

¹University of Colorado-Denver Health Sciences Center (UCDHSC), Department of Internal Medicine, Division of General Internal Medicine, Denver, CO 80045, USA. Amy.Huebschmann@uchsc.edu

Clinical Interventions in Aging

|December 1, 2007

Summary

This summary is machine-generated.

Elderly patients (aged 65+) received different antihypertensive medications than younger adults. Diuretic and calcium-channel blocker use aligned with guidelines, but alpha-blocker use may relate to comorbidities or pose risks.

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Last Updated: Jul 9, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Area of Science:

Geriatric Medicine
Cardiovascular Pharmacology
Health Services Research

Background:

Antihypertensive medication prescribing patterns may differ between elderly and younger populations.
Understanding these differences is crucial for optimizing treatment and adhering to national guidelines.

Purpose of the Study:

To investigate variations in antihypertensive drug classes prescribed for elderly versus younger patients.
To assess adherence to national hypertension treatment guidelines in different age groups.

Main Methods:

Analysis of the National Ambulatory Medical Care Survey (NAMCS) database from 1995-2000.
Inclusion of over 332 million outpatient visits for hypertension diagnoses.
Examination of prescribed antihypertensive medications and patient demographics.

Main Results:

A significant association was found between age (≥65 years) and the prescription of diuretics, calcium-channel blockers (CCBs), alpha-1-blockers (A1Bs), and alpha-2 agonists (A2Ags).
Prescribing patterns for diuretics and CCBs in older adults were consistent with evidence-based guidelines.

Conclusions:

Older adults (≥65 years) were prescribed distinct antihypertensive agents compared to younger individuals.
While diuretic and CCB use in the elderly aligns with guidelines, A1B use may be influenced by comorbidities like benign prostatic hyperplasia (BPH).
Increased A2Ag prescription in the elderly warrants caution due to potential cognitive side effects.