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Assembly and Purification of Prototype Foamy Virus Intasomes
Published on: March 19, 2018
[Indinavir-associated tubulointerstitial renal disease]
Raymonde F Gagnon1, Amira Mehio, Sameena Iqbal
1Département de médecine, centre hospitalier de l'université McGill, Montréal, Canada. raymonde.gagnon@muhc.mcgill.ca
Nephrologie & Therapeutique
|December 1, 2007
Summary
Indinavir crystalluria can cause kidney damage in HIV patients. This case highlights how drug crystals impact the renal tubulointerstitial compartment, potentially necessitating treatment changes.
Area of Science:
- Nephrology
- Infectious Diseases
- Pharmacology
Background:
- Indinavir is an antiretroviral medication used to treat HIV/AIDS.
- Indinavir is known to cause crystalluria, which can lead to urinary tract abnormalities.
Observation:
- A case of progressive leucocyturia (white blood cells in urine) and renal impairment developed during indinavir therapy.
- The patient experienced adverse effects related to indinavir-induced crystalluria.
Findings:
- Indinavir crystalluria significantly impacts the tubulointerstitial compartment of the kidney.
- The crystalluria led to observable renal damage and increased white blood cells in the urine.
Implications:
- Clinicians should monitor renal function in patients treated with indinavir.
- Understanding the renal impact of indinavir crystalluria is crucial for managing HIV patients.
- Crystalluria-associated nephrotoxicity may require dose adjustment or drug discontinuation.
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