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Alkaloids and saponins from blue cohosh
1National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi, MS 38677, USA.
Abstract:
Blue cohosh, Caulophyllum thalictroides (L.) Michx. (Berberidaceae), is used primarily to cure menstrual disturbances and to ease childbirth. Alkaloids and saponins are considered to be responsible for its pharmacological activity. A detailed phytochemical investigation of blue cohosh resulted in the isolation of 15 compounds belonging to the alkaloids and the triterpene saponins. The structures of two alkaloids, caulophyllumines A (1) and B (2) and a saponin, cauloside H (3) both previously unknown were determined by spectroscopic techniques, including by 1- and 2-D NMR as well as by chemical analysis.
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