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Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...

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Related Experiment Video

Updated: Jul 9, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Editorial: research progress in early-onset schizophrenia.

Sanjiv Kumra, S Charles Schulz

    Schizophrenia Bulletin
    |December 1, 2007
    PubMed
    Summary

    Early-onset schizophrenia (EOS) in patients under 18 shares neurobiological similarities with adult-onset forms but presents with more severe developmental issues and genetic factors. This suggests EOS may represent a more severe schizophrenia subtype.

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Genetics

    Background:

    • Schizophrenia onset can occur before age 18, with early-onset schizophrenia (EOS) presenting distinct characteristics.
    • Phenomenological, cognitive, neuroimaging, and genetic data indicate similarities and differences between EOS and adult-onset schizophrenia.

    Discussion:

    • EOS patients exhibit more severe premorbid neurodevelopmental abnormalities, poorer long-term outcomes, and increased cytogenetic anomalies.
    • A greater familial loading for schizophrenia spectrum disorders is observed in EOS.
    • These findings support the hypothesis that EOS is a more severe form of schizophrenia with a stronger genetic predisposition.

    Key Insights:

    • Early-onset schizophrenia may be a distinct, more severe subtype.
    • Genetic predisposition and neurodevelopmental factors play a crucial role in EOS.

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    Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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    Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
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    Published on: November 21, 2013

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    Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
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  • Similarities in neurobiology exist between early- and adult-onset schizophrenia.

    • Outlook:

    • Future research on EOS cohorts will utilize advanced neuroimaging and genetic studies.
    • Investigating the neurodevelopmental origins of schizophrenia is a key focus.
    • Understanding the interplay of genetic and environmental factors in schizophrenia susceptibility and phenotype is anticipated.