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Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
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Published on: December 11, 2013

Risk assessment in the patient with established peripheral arterial disease

Scott Haugen1, Ivan P Casserly, Judith G Regensteiner

  • 1Divisions of Cardiology and General Internal Medicine, Department of Medicine, University of Colorado School of Medicine, Denver, CO, USA.

Vascular Medicine (London, England)
|December 1, 2007
PubMed

Insights

Cardiovascular risk in peripheral arterial disease (PAD) patients is high. Emerging inflammatory markers like C-reactive protein (CRP) may improve risk prediction beyond traditional factors and the ankle-brachial index (ABI).

Area of Science:

  • Cardiology
  • Vascular Medicine
  • Inflammation Research

Background:

  • Cardiovascular risk prediction in primary and secondary settings presents challenges for practitioners.
  • Patients with established peripheral arterial disease (PAD) face a high risk of cardiovascular events.
  • Traditional risk factors and the ankle-brachial index (ABI) offer incomplete secondary risk prediction in PAD.

Purpose of the Study:

  • To review the utility of the ankle-brachial index (ABI), clinical disease stage, and inflammatory markers for secondary risk prediction in PAD.
  • To explore emerging markers, such as C-reactive protein (CRP), for improved cardiovascular risk stratification in PAD patients.

Main Methods:

  • Literature review evaluating the role of ABI, clinical staging, C-reactive protein (CRP), and other inflammatory markers.
  • Analysis of surrogate markers for systemic atherosclerotic burden and inflammation in PAD.

Main Results:

  • The ankle-brachial index (ABI) and traditional risk factors are insufficient for complete secondary risk prediction in PAD.
  • Inflammatory markers, including C-reactive protein (CRP), show emerging utility in enhancing cardiovascular risk stratification for PAD patients.

Conclusions:

  • Improved secondary risk prediction in PAD can be achieved by incorporating markers of systemic inflammation.
  • Accurate identification of high-risk PAD patients can guide intensified preventive measures and improve adherence to therapies and smoking cessation.

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