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Related Experiment Video

Updated: Jul 9, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

The ABCs of CMV.

Jennifer DeVries¹

¹Duke University Medical Center, Durham, NC, USA. devri002@mc.duke.edu

Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses

|December 1, 2007

Summary

Most infants exposed to cytomegalovirus (CMV) in utero are asymptomatic. Symptomatic congenital CMV infection in newborns leads to severe outcomes, emphasizing the need for preventative strategies.

Area of Science:

Neonatal Health
Infectious Diseases
Maternal-Fetal Medicine

Background:

Congenital cytomegalovirus (CMV) infection is a significant concern in newborns.
While most in utero exposures are asymptomatic, symptomatic cases have severe consequences.

Purpose of the Study:

To summarize the clinical characteristics and outcomes of congenital CMV infection.
To highlight the limitations in current treatment and the need for preventative measures.

Main Methods:

Review of existing literature on congenital CMV infection.
Analysis of clinical manifestations and prognostic factors.

Main Results:

Symptomatic congenital CMV infection is associated with poorer prognosis compared to asymptomatic cases.

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qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue

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Last Updated: Jul 9, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

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Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

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qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue

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Published on: July 9, 2014

Timing of maternal infection during pregnancy influences fetal outcomes.

Physical characteristics include microcephaly, intrauterine growth restriction, and organomegaly.

Conclusions:

Congenital CMV infection poses risks, particularly symptomatic cases.
Limited treatment options necessitate a focus on prevention.
Development of a vaccine or preventative treatment is a priority in the US.