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Related Experiment Video

Updated: Jul 9, 2026

Simultaneous Visualization of the Dynamics of Crosslinked and Single Microtubules In Vitro by TIRF Microscopy

Simultaneous Visualization of the Dynamics of Crosslinked and Single Microtubules In Vitro by TIRF Microscopy

Published on: February 18, 2022

Some guidelines on guidelines: they should come with expiration dates.

Kenneth J Rothman¹, Charles Poole

¹RTI Health Solutions, RTI International, Research Triangle Park, NC 27709, USA. krothman@rti.org

Epidemiology (Cambridge, Mass.)

|December 1, 2007

Summary

The Strengthening the Reporting of OBservational Studies in Epidemiology (STROBE) guidelines aim to improve research clarity. However, this study suggests guidelines may become outdated, proposing an expiration date to encourage timely revisions.

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Last Updated: Jul 9, 2026

Simultaneous Visualization of the Dynamics of Crosslinked and Single Microtubules In Vitro by TIRF Microscopy

Simultaneous Visualization of the Dynamics of Crosslinked and Single Microtubules In Vitro by TIRF Microscopy

Published on: February 18, 2022

Area of Science:

Epidemiology
Research Methodology
Scientific Publishing

Background:

Guidelines are crucial for standardizing scientific reporting.
The Strengthening the Reporting of OBservational Studies in Epidemiology (STROBE) guidelines aim to enhance the quality of observational studies.
However, the longevity and potential for guidelines to become outdated are significant concerns in scientific research.

Purpose of the Study:

To evaluate the long-term utility of scientific guidelines, specifically the STROBE guidelines.
To address the issue of guideline ossification and potential counterproductivity.
To propose a mechanism for ensuring the continued relevance of epidemiological reporting standards.

Main Methods:

Critical analysis of the concept of scientific guidelines and their historical evolution.
Discussion of the inherent limitations of static guidelines in rapidly advancing fields.
Proposal of a time-bound expiration policy for scientific guidelines.

Main Results:

The STROBE guidelines, while ambitious, face the generic problem of potential obsolescence.
Static guidelines can lead to ossification and hinder scientific progress.
Historical examples demonstrate the limited usefulness of outdated epidemiological guidelines.

Conclusions:

Scientific guidelines, including STROBE, require regular updates to remain effective.
Implementing an expiration date for guidelines, such as STROBE, would prompt necessary revisions.
A policy of guideline expiration, e.g., December 31, 2010, or three years post-revision, is suggested to maintain relevance.