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Low-grade inflammation in white-coat hypertension

Mustafa Ozdogan1, Hakan Bozcuk, Erkan Coban

  • 1Department of Internal Medicine, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|December 1, 2007
PubMed

Insights

White-coat hypertension patients exhibit elevated high-sensitivity C-reactive protein (hs-CRP) levels compared to normotensive individuals. This finding suggests a potential increased cardiovascular risk associated with white-coat hypertension.

Area of Science:

  • Cardiology
  • Inflammation Research
  • Hypertension Studies

Background:

  • C-reactive protein (CRP) indicates inflammation and predicts cardiovascular risk in essential hypertension.
  • The cardiovascular risk profile of white-coat hypertension remains unclear.
  • Investigating high-sensitivity CRP (hs-CRP) in white-coat hypertension is crucial.

Purpose of the Study:

  • To assess high-sensitivity C-reactive protein (hs-CRP) levels in individuals with white-coat hypertension.
  • To compare hs-CRP levels between white-coat hypertensive, essential hypertensive, and normotensive subjects.

Main Methods:

  • A comparative study involving 36 white-coat hypertensive, 36 essential hypertensive, and 36 normotensive subjects.
  • Participants were matched for age, sex, and body mass index.
  • Measurement of high-sensitivity C-reactive protein (hs-CRP) levels.

Main Results:

  • Hs-CRP levels were significantly elevated in both essential hypertensive and white-coat hypertensive groups compared to normotensive controls (p<0.001).
  • Essential hypertensive patients showed higher hs-CRP levels than white-coat hypertensive patients (p=0.014).
  • White-coat hypertensive subjects had significantly higher hs-CRP levels than normotensive subjects.

Conclusions:

  • Patients with white-coat hypertension demonstrate elevated hs-CRP levels compared to normotensive individuals.
  • Higher hs-CRP in white-coat hypertension may signify an increased cardiovascular risk.
  • Further research is warranted to elucidate the prognostic implications of hs-CRP in white-coat hypertension.
Abstract

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