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Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
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Autoreactive B cells get activated in extrafollicular sites

Florian Weisel1, Ute Wellmann, Thomas H Winkler

  • 1Hematopoiesis Unit, Institute for Biology, Nikolaus-Fiebiger-Center for Molecular Medicine, University Erlangen-Nuremberg, Germany.

European Journal of Immunology
|December 1, 2007
PubMed
Summary

Researchers developed a new model to study autoreactive B cells in autoimmune diseases. This model uses chromatin-containing immune complexes to induce B cell activation and hypermutation at extrafollicular sites.

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