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Quantitative Magnetic Resonance Imaging of Skeletal Muscle Disease
Published on: December 18, 2016
Hypomagnesemia associated with chondrocalcinosis: a cross-sectional study.
Pascal Richette1, Ghazi Ayoub, Sophie Lahalle
1Assistance Publique Hôpitaux de Paris, Hôpital Lariboisière, Paris, France. pascal.richette@lrb.aphp.fr
Arthritis and Rheumatism
|December 1, 2007
Summary
Magnesium (Mg) depletion is strongly linked to chondrocalcinosis. This study found a significantly higher prevalence of chondrocalcinosis in patients with magnesium depletion.
Area of Science:
- Mineral metabolism research
- Orthopedic research
- Clinical nutrition
Background:
- Chondrocalcinosis prevalence has been reported in relation to magnesium (Mg) depletion.
- Previous investigations have not utilized a cross-sectional study design.
Purpose of the Study:
- To determine the association between magnesium depletion and chondrocalcinosis.
- To investigate the prevalence of chondrocalcinosis in patients receiving home parenteral nutrition (HPN).
Main Methods:
- A cross-sectional study compared 72 patients on HPN with 72 matched controls.
- Chondrocalcinosis presence was assessed via knee radiographs.
- Serum, globular, and 24-hour urinary magnesium levels were compared between groups.
Main Results:
- Chondrocalcinosis was significantly more prevalent in HPN patients (16.6%) versus controls (2.7%).
- HPN patients exhibited lower mean serum, globular, and 24-hour urinary magnesium levels.
- Low serum magnesium levels strongly correlated with increased chondrocalcinosis prevalence (OR 13.5).
Conclusions:
- Long-lasting magnesium depletion is strongly associated with chondrocalcinosis.
- Maintaining adequate magnesium levels may be crucial for preventing chondrocalcinosis in patients with HPN.
