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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

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Ratiometric Calcium Imaging of Individual Neurons in Behaving Caenorhabditis Elegans
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LIN-12/Notch signaling in C. elegans.

Iva Greenwald1

  • 1Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biophysics, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA. greenwald@cancercenter.columbia.edu

Wormbook : the Online Review of C. Elegans Biology
|December 1, 2007
PubMed
Summary
This summary is machine-generated.

The LIN-12/Notch pathway, crucial for animal development, is explored using C. elegans genetics. This research identifies key components and regulators of this signaling pathway, vital for understanding cell fate and human disease.

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Area of Science:

  • Developmental Biology
  • Genetics
  • Cell Signaling

Background:

  • LIN-12/Notch receptors mediate cell-cell interactions essential for animal development.
  • Dysregulation of LIN-12/Notch signaling is linked to various human diseases.
  • C. elegans has been a powerful model organism for dissecting fundamental biological pathways.

Purpose of the Study:

  • To detail the significant contributions of C. elegans genetics to understanding the LIN-12/Notch pathway.
  • To highlight the identification of core components and modulators of LIN-12/Notch activity.
  • To provide insights into the mechanism of signal transduction and regulation within this pathway.

Main Methods:

  • Leveraging the genetic tractability of C. elegans.
  • Employing genetic screens to identify novel components and modulators.
  • Utilizing forward and reverse genetics approaches.

Main Results:

  • Identification of numerous genes critical for LIN-12/Notch receptor function.
  • Elucidation of the roles of these genes in signal transduction and pathway regulation.
  • Characterization of LIN-12/Notch pathway components and their impact on cell fate decisions.

Conclusions:

  • C. elegans genetics provides a powerful platform for dissecting complex signaling pathways like LIN-12/Notch.
  • The identified components and modulators are crucial for understanding normal development and disease pathogenesis.
  • Further research in C. elegans will continue to illuminate the intricacies of LIN-12/Notch signaling.