Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epidermal morphogenesis.

Andrew D Chisholm1, Jeff Hardin

  • 1Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.

Wormbook : the Online Review of C. Elegans Biology
|December 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cellular Processes and Forces Shaping the Embryo: Lessons from <i>C. elegans</i>.

Cells·2026
Same author

TEP-1, a glial thioester protein is required for cilia organization and intraflagellar transport in ensheathed sensory neurons in <i>Caenorhabditis elegans</i>.

Molecular biology of the cell·2026
Same author

Keeping a stiff upper lip: p120ctn and tissue fusion.

The Journal of cell biology·2025
Same author

TEP-1, a glial thioester protein is required for cilia organization and intraflagellar transport in ensheathed sensory neurons.

bioRxiv : the preprint server for biology·2025
Same author

Phospholipid biogenesis maintains neuronal integrity during aging and axon regeneration.

Genetics·2025
Same author

Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging.

bioRxiv : the preprint server for biology·2025
Same journal

Caenorhabditis nomenclature.

WormBook : the online review of C. elegans biology·2018
Same journal

Tubulins in C. elegans.

WormBook : the online review of C. elegans biology·2018
Same journal

History of research on C. elegans and other free-living nematodes as model organisms.

WormBook : the online review of C. elegans biology·2017
Same journal

Development, structure, and maintenance of C. elegans body wall muscle.

WormBook : the online review of C. elegans biology·2016
Same journal

Working with dauer larvae.

WormBook : the online review of C. elegans biology·2016
Same journal

Small GTPases.

WormBook : the online review of C. elegans biology·2016
See all related articles

The C. elegans epidermis (hypodermis) guides embryo development through cell rearrangement, enclosure, and elongation. Genetic studies reveal key transcription factors and cellular behaviors controlling this essential morphogenesis.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • The C. elegans epidermis (hypodermis) is a single epithelial layer crucial for embryo morphogenesis.
  • Epidermal development involves complex cell-cell interactions with internal tissues like the nervous system and musculature.

Purpose of the Study:

  • To elucidate the genetic control and cellular mechanisms underlying epidermal morphogenesis in C. elegans.

Main Methods:

  • Genetic analysis of mutants with abnormal epidermal morphology.
  • Observation of cellular behaviors during epidermal development, including rearrangement, enclosure, and elongation.

Main Results:

  • Identified a hierarchy of transcription factors regulating epidermal fate specification.

Related Experiment Videos

  • Described distinct cellular behaviors driving ventral enclosure and epidermal elongation.
  • Highlighted the roles of cytoskeletal elements (actin, microtubules, intermediate filaments) and body wall muscles in elongation.

    • Conclusions:

    • Epidermal morphogenesis in C. elegans is a multi-step process regulated by genetic factors and intricate cellular dynamics.
    • Understanding these processes provides insights into fundamental mechanisms of epithelial development and tissue formation.