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Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
Types of Receptors: Internal Receptors01:07

Types of Receptors: Internal Receptors

Many cellular signals are hydrophilic and cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind intracellular receptors that reside within the cell cytoplasm or nucleus. Many mammalian steroid hormones and nitric oxide (NO) gas use this cell signaling mechanism.
Similar to membrane-bound receptors, the binding of a ligand to the intracellular receptor of causes a conformational change in the...

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Related Experiment Video

Updated: Jul 9, 2026

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay
08:56

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

Published on: May 5, 2020

Nuclear hormone receptors in C. elegans.

Adam Antebi1

  • 1Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA. aantebi@bcm.tmc.edu

Wormbook : the Online Review of C. Elegans Biology
|December 1, 2007
PubMed
Summary

Nuclear receptors (NRs) coordinate key life processes in animals. This study explores the large NR family in C. elegans, revealing their roles in development, metabolism, and neural functions.

Area of Science:

  • * Molecular Endocrinology
  • * Developmental Biology
  • * Genomics

Background:

  • * Nuclear receptors (NRs) are crucial transcription factors regulating metabolism, development, and homeostasis in metazoans.
  • * The nematode C. elegans possesses an expanded NR family with 284 members, significantly more than other metazoans.
  • * Genetic analysis of approximately 20 C. elegans NRs indicates conserved roles in fundamental biological processes.

Purpose of the Study:

  • * To investigate the diverse functions of the expanded nuclear receptor family in Caenorhabditis elegans.
  • * To understand the role of C. elegans NRs in coordinating complex endocrine networks.
  • * To leverage C. elegans as a model for dissecting in vivo nuclear receptor signaling pathways.

Main Methods:

  • * Genetic analysis of C. elegans nuclear receptors.

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Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes
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Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans
09:36

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans

Published on: July 30, 2018

Related Experiment Videos

Last Updated: Jul 9, 2026

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay
08:56

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

Published on: May 5, 2020

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes
18:38

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans
09:36

Detecting Protein Subcellular Localization by Green Fluorescence Protein Tagging and 4',6-Diamidino-2-phenylindole Staining in Caenorhabditis elegans

Published on: July 30, 2018

  • * Comparative genomics to identify conserved NR homologs.
  • * Investigation of NR involvement in life history traits, neural development, and metabolism.

    • Main Results:

    • * C. elegans NRs influence critical life history traits including sex determination, molting, developmental timing, diapause, and lifespan.
    • * These receptors are implicated in neural development, governing axon outgrowth and neuronal identity.
    • * C. elegans NRs play a significant role in regulating lipid and xenobiotic metabolism.

    Conclusions:

    • * The extensive C. elegans NR repertoire underscores their importance in coordinating complex biological functions.
    • * Studying C. elegans NRs provides valuable insights into conserved endocrine signaling pathways.
    • * C. elegans serves as a powerful model organism for in vivo studies of nuclear receptor function within intricate endocrine systems.