Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell division.

Karen Oegema1, Anthony A Hyman

  • 1Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA. koegema@ucsd.edu

Wormbook : the Online Review of C. Elegans Biology
|December 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phosphorylation remodels the mitotic centrosome matrix to generate bipartite γ-tubulin complex docking sites.

Science advances·2026
Same author

Stress Granule Sequestration of CCR4-NOT Promotes Poly(A) Lengthening of Stress-Survival Transcripts.

bioRxiv : the preprint server for biology·2026
Same author

A chromatin-associated pool of Aurora A controls kinetochore-microtubule attachments to ensure chromosome biorientation.

Science advances·2026
Same author

A conserved motif tunes Sidekick condensate dynamics to control tricellular junction recruitment during epithelial remodeling.

Cell reports·2026
Same author

Inhibitor-2 directs formation of PP1 holoenzymes through a docking motif-dependent transfer of catalytic subunits to adapters.

bioRxiv : the preprint server for biology·2026
Same author

Biomolecular condensates mediate C-N bond formation.

Nature chemical biology·2026
Same journal

Caenorhabditis nomenclature.

WormBook : the online review of C. elegans biology·2018
Same journal

Tubulins in C. elegans.

WormBook : the online review of C. elegans biology·2018
Same journal

History of research on C. elegans and other free-living nematodes as model organisms.

WormBook : the online review of C. elegans biology·2017
Same journal

Development, structure, and maintenance of C. elegans body wall muscle.

WormBook : the online review of C. elegans biology·2016
Same journal

Working with dauer larvae.

WormBook : the online review of C. elegans biology·2016
Same journal

Small GTPases.

WormBook : the online review of C. elegans biology·2016
See all related articles

The C. elegans embryo offers a robust model for studying cell division mechanics. RNA interference (RNAi) in oocytes allows precise gene depletion for analyzing mitotic events and discoveries in key cellular processes.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • The C. elegans embryo is a widely used model for metazoan cell division research.
  • Its syncytial gonad architecture facilitates targeted gene silencing using RNA interference (RNAi).

Purpose of the Study:

  • To outline the utility of the C. elegans embryo for cell division studies.
  • To summarize recent discoveries in key cell division processes using this model system.

Main Methods:

  • Utilizing RNA interference (RNAi) to deplete essential gene products in C. elegans oocytes.
  • Analyzing first mitotic divisions in these depleted oocytes post-fertilization.

Main Results:

  • Demonstrated reproducible depletion (>95%) of targeted essential gene products.

Related Experiment Videos

  • Provided a timeline and key features of the first embryonic mitosis.
  • Highlighted recent discoveries in nuclear envelope dynamics, centrosome behavior, spindle formation, kinetochore assembly, chromosome segregation, and cytokinesis.

    • Conclusions:

    • The C. elegans embryo is an advantageous model for dissecting the mechanics of cell division.
    • RNAi-mediated depletion enables detailed analysis of essential gene functions in mitosis.
    • This system has facilitated significant advancements in understanding fundamental cell division processes.