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Introduction to Membrane Traffic

Introduction to Membrane Traffic

The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...

Introduction to Membrane Traffic

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Related Experiment Video

Updated: Jul 9, 2026

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis

Published on: July 3, 2015

Intracellular trafficking.

Barth D Grant¹, Miyuki Sato

¹Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA. grant@biology.rutgers.edu

Wormbook : the Online Review of C. Elegans Biology

|December 1, 2007

Summary

This summary is machine-generated.

Caenorhabditis elegans studies reveal new intracellular membrane traffic mechanisms. This research explores endocytic and secretion pathways in diverse cell types of this multicellular organism.

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Last Updated: Jul 9, 2026

Tracking Drug-induced Changes in Receptor Post-internalization Trafficking by Colocalizational Analysis

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Brain Slice Biotinylation: An Ex Vivo Approach to Measure Region-specific Plasma Membrane Protein Trafficking in Adult Neurons

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Area of Science:

Cell Biology
Developmental Biology
Genetics

Background:

Intracellular membrane traffic is crucial for cellular function.
Caenorhabditis elegans offers a genetically tractable model for studying complex biological processes.
Understanding these pathways is key to comprehending multicellular development.

Purpose of the Study:

To review recent advancements in understanding intracellular membrane traffic in C. elegans.
To highlight the roles of endocytic and secretion pathways in diverse cell types.
To explore how these conserved pathways are modified in a multicellular context.

Main Methods:

Genetic analysis in C. elegans.
Cellular imaging and microscopy.
Functional assays for membrane trafficking.

Main Results:

Identification of novel components and mechanisms in endocytosis and secretion.
Elucidation of pathway dynamics in the worm germ line and coelomocytes.
Insights into the specialized roles of membrane traffic in muscle, nerve, and epithelial cells.

Conclusions:

C. elegans is a powerful model for dissecting intracellular membrane traffic.
These pathways are essential for development and cell differentiation.
Further research in C. elegans will continue to uncover fundamental biological mechanisms.