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Updated: Jul 9, 2026

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Published on: January 9, 2026
Sigmoid colon cancer with mediastinal lymph node metastases
Masahiro Tsubaki1, Kazuhiro Nemoto, Norihito Yoda
1First Department of Surgery, Dokkyo University, School of Medicine, Shimotsugagun, Tochigi, Japan. mtsubaki@dokkyomed.ac.jp
Mediastinal lymph node metastasis from sigmoid colon cancer is rare. This case highlights a patient with brain and mediastinal metastases, emphasizing the need for thorough staging in colorectal cancer.
Area of Science:
- Oncology
- Gastroenterology
- Radiology
Background:
- Colorectal cancer rarely metastasizes to mediastinal lymph nodes.
- Distant metastasis in colorectal cancer necessitates comprehensive staging.
Observation:
- A 74-year-old male presented with multiple brain tumors and a mediastinal mass.
- Imaging revealed brain lesions and a mediastinal tumor suspicious for metastasis.
- Biopsy confirmed metastatic adenocarcinoma from a digestive tract primary.
Findings:
- The primary tumor was identified as sigmoid colon adenocarcinoma.
- Despite extensive metastasis, the surgical specimen showed no lymph node involvement.
- The patient had a poor prognosis, succumbing to the disease within months.
Implications:
- This case underscores the unusual presentation of colorectal cancer metastasis.
- It highlights the importance of advanced imaging in detecting rare metastatic sites.
- Further research into the mechanisms of rare metastatic patterns is warranted.
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