Related Experiment Video
Updated: Jul 9, 2026

Analytical Techniques for Assaying Nitric Oxide Bioactivity
Published on: June 18, 2012
[Does nitroglycerin show the properties of a selective venodilator?]
Abstract:
The central hemodynamic effect of continuous intravenous nitroglycerin infusion at an increasing rate (0.01-0.1 microg x kg(-1) x min(-1)) was evaluated by noninvasive (tetrapolar rheography) and invasive (pulmonary arterial catheterization) techniques. The study included 10 healthy volunteers and 30 patients having usual indications for nitroglycerin infusion. The findings suggest that when even infused at low rates, nitroglycerin canses mainly arteriolar vasodilatation, which appears as increased stroke volume due to the predominance of diminished postload over lowered preload. It is obvious that the notion of nitroglycerin as a selective venodilator should be revised.
More Related Videos
Related Concept Videos
Antihypertensive Drugs: Vasodilators
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
Nitric Oxide Signaling Pathway
Adrenergic Agonists: Direct-Acting Agents
These agents can be classified...
Dose-Response Relationship: Selectivity and Specificity
Heart Failure Drugs: β-Blockers

