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[Expression and clinical significance of Endostatin, vascular endothelial growth factor and fibroblast growth factor
Wei-wei Liu1, Shu-jun Zhang, Guang-huai Han
1Department of Otorhinolaryngology, The Four Affiliated Hospital of Hebei Medical University, Shijiazhuang 050011, China. lwwczbj@163.com
Objective:
To evaluate the expression and clinical significance of Endostatin, vascular endothelial growth factor (VEGF) and fibroblast growth factor basic-2 (FGF-2) in the laryngeal squamous cell carcinoma (LSCC).
Methods:
The expression of Endostatin, VEGF and FGF-2 in 50 specimens of LSCC, 40 specimens of para-carcinoma and 10 specimens of normal laryngeal tissues were examined by Flow cytometry.
Results:
Compared with para-carcinoma and normal laryngeal tissues, the expression level and positive rate of Endostatin, VEGF, FGF-2 in LSCC were different in statistics (P < 0.05); the expression level and positive rate of endostatin, VEGF, FGF-2 in LSCC are obviously higher than those in para-carcinoma and normal laryngeal tissues. The expression level and positive rate of Endostatin, VEGF, FGF-2 were no difference in statistics between para-carcinoma and normal laryngeal tissues (P > 0.05). The expression level and positive rate of Endostatin, VEGF, FGF-2 in LSCC were associated with lymphoid metastasis and clinical stage, not associated with age, sex and clinical group.
Conclusions:
Endostatin, VEGF and FGF-2 play important role in the incidence, development and prognosis of the LSCC.
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