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Inhibition of human immunodeficiency virus type I replication by derivatives of gossypol
R E Royer1, R G Mills, L M Deck
1Department of Biochemistry, University of New Mexico School of Medicine, Albuquerque 87131.
Pharmacological Research
|December 1, 1991
Abstract:
Gossypol (I) and its derivatives gossylic nitrile-1,1'-diacetate (II), gossylic iminolactone (III) and gossylic lactone (IV) inhibit the replication of human immunodeficiency virus type 1 in vitro in the order III greater than I greater than II,IV, indicating that derivatives of gossypol can retain antiviral activities. All of the derivatives are less cytotoxic than gossypol.