A formal synthesis of the callipeltoside aglycone
James A Marshall1, Patrick M Eidam
1Department of Chemistry, University of Virginia, PO Box 40019, Charlottesville, Virginia 22904, USA. jam5x@virginia.edu
Organic Letters
|December 7, 2007
Abstract:
A synthesis of the macrocyclic core structure of callipeltoside A and a C9 epimer has been achieved by applications of chiral vinylzinc or Kishi-Nozaki-Hiyama (K-N-H) additions, Roskamp homologations, and acylketene or intramolecular K-N-H macrolactonizations as key bond-forming steps.
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