Time course of interictal EEG patterns induced by a penicillin injection into the olfactory cortex

In awake rats, the time courses of behavioural and cortical interictal hyperactivity patterns were investigated following an injection of the GABA antagonist Na-penicillin (PCN) (125 IU/0.5 microliters) into the olfactory or motor cortex. The cortical EEG was recorded by means of 6 AgAgCl-electrodes, behaviour was videotaped simultaneously. Behavioural hyperactivity developed immediately after PCN injection. It lasted longer than 2.5 to 4 h in the olfactory but less than 30 min in the motor cortex group of rats. The interictal EEG pattern of the olfactory group was characterized by a slow establishing of three centers of high cortical activity. They were located in the ipsilateral central and the contralateral frontal and occipital cortex. In the motor cortex group, however, a cortical center of high activity developed immediately after the PCN injection near the injection site only, or additionally, over the homotopic area of the contralateral hemisphere. The results indicate different susceptibility properties in the underlying neuronal networks. Ongoing epileptiform activity obviously modifies this susceptibility in a site-specific manner. Moreover, the time-correlated occurrence of high activity in the frontal motor and occipital cortex evoked by a PCN injection into the olfactory cortex suggests a close coupling of these three areas. A coupling between the frontal motor, occipital and focal area could not be shown, if PCN was injected into the motor cortex.