Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Micturition Reflex01:26

The Micturition Reflex

Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating urine...
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs like...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Diabetes Insipidus II: Pathophysiology01:22

Diabetes Insipidus II: Pathophysiology

Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neurocorrelates of nocturnal enuresis in pre-adolescent children.

Journal of pediatric urology·2026
Same author

Commentary to "Impaired toilet training and bladder and bowel dysfunction in children with developmental coordination disorder - an underreported issue".

Journal of pediatric urology·2026
Same author

Toileting dysfunction in SATB2-associated syndrome: results from a caregiver survey.

Journal of pediatric urology·2026
Same author

Moving toward a corticocentric view of pediatric urinary incontinence.

Journal of pediatric urology·2026
Same author

Peak systolic velocity, not vein size, predicts abnormal sperm count in adolescent Tanner V patients with primary left varicocele.

Journal of pediatric urology·2026
Same author

Response to Commentary on "Are rhythmic bladder contractions affected by fill rate and bladder work in neurogenic bladders".

Journal of pediatric urology·2025

Related Experiment Video

Updated: Jul 9, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Pediatric overactive bladder syndrome: pathophysiology and management.

Israel Franco1

  • 1Section of Pediatric Urology, New York Medical College, Valhalla, NY, USA. isfranco@optonline.net

Paediatric Drugs
|December 7, 2007
PubMed
Summary

Overactive bladder syndrome (OAB) in children is a common voiding dysfunction linked to broader neurological issues affecting multiple systems, not just the bladder. New research suggests a central nervous system origin, requiring a shift towards understanding brain-based mechanisms for effective treatment.

More Related Videos

Real-Time Void Spot Assay
06:39

Real-Time Void Spot Assay

Published on: February 10, 2023

Related Experiment Videos

Last Updated: Jul 9, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
03:26

Detrusor Underactivity Model in Rats by Conus Medullaris Transection

Published on: August 28, 2020

Real-Time Void Spot Assay
06:39

Real-Time Void Spot Assay

Published on: February 10, 2023

Area of Science:

  • Pediatric Urology
  • Neuroscience
  • Developmental Biology

Background:

  • Overactive bladder syndrome (OAB), a common pediatric voiding dysfunction, was historically viewed as a primary bladder issue or a developmental delay.
  • Recent studies suggest OAB in children may be linked to adult voiding dysfunctions and associated with sexual and neuropsychiatric problems.
  • Emerging evidence indicates OAB might be a symptom of a more generalized, centrally located dysfunction impacting multiple bodily systems.

Purpose of the Study:

  • To review the neuroanatomy, neurophysiology, and neuropharmacology of pediatric voiding.
  • To integrate urologic and non-urologic research to develop a unified theory for pediatric OAB.
  • To explore current and future treatment modalities for pediatric OAB.

Main Methods:

  • Comprehensive literature review of urologic and related scientific fields.
  • Analysis of neuroanatomy and neurophysiology of the lower urinary tract.
  • Evaluation of neuropharmacological agents and treatment strategies.

Main Results:

  • Pediatric OAB and voiding dysfunctions appear to be part of a generalized condition affecting the bowels, bladder, sexual function, blood pressure regulation, mood, and behavior.
  • Strong associations exist between pediatric OAB, bowel dysfunction, and neuropsychiatric conditions.
  • Current data suggest a shift from a bladder-centric to a brain-centric understanding of OAB is necessary.

Conclusions:

  • Pediatric OAB is likely a symptom of a multi-system neurodevelopmental disorder with central origins.
  • A corticocentric approach, supported by advanced brain imaging, is crucial for future OAB management in children.
  • Future treatments should aim to address the underlying disease process rather than solely managing symptoms.